Deprotection of Trimethylsilyl and Tetrahydropyranyl Ethers and of Ethylene Acetals with Tetramethylammonium Chlorochromate

Abstract

This paper describes the preparation of tetramethylammonium chlorochromate (TMACC) as a new and efficient reagent for the oxidative deprotection of trimethylsilyl and tetrahydropyranyl ethers or ethylene acetals and ketals to the corresponding carbonyl compounds in refluxing acetonitrile in the presence of catalytic amounts of aluminum chloride.

Acknowledgments

We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology (IUT), IR, Iran (A. R. H.) and Grant GM 33138 (A. E. R.) from the National Institutes of Health, USA.