Synthesis of Kojic Acid Derivatives Containing Phenolic Hydroxy Groups

J. Kadokawa Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Japan; Department of Materials Chemistry, Graduate School of Engineering, Tohoku University, Aoba 07, Aoba-ku, Sendai 980-8579, Japan Fax: E-mail: [email protected]

T. Nishikura Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Japan

R. Muraoka Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Japan

H. Tagaya Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University, Yonezawa, Japan

N. Fukuoka Chemipro Kasei Kaisha Ltd., Chuo-ku, Kobe, Japan

Abstract

Two kojic acid derivatives (2a and 2b) containing phenolic hydroxy groups were synthesized. The preparation was carried out by the reaction of a kojic acid derivative (3) having a chloromethyl group with phenol derivatives (4 and 7), followed by the subsequent deprotection steps. The first reaction proceeded smoothly in the presence of potassium carbonate in DMF at room temperature. Then, the appropriate deprotection reactions gave the desired compounds 2a and 2b. The structures of 2a and 2b were confirmed by the ¹H NMR spectra.

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Acknowledgment

We are indebted to Ms. Masa Karasu of our research group for her technical assistance.

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Synthesis of Kojic Acid Derivatives Containing Phenolic Hydroxy Groups

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Synthesis of Kojic Acid Derivatives Containing Phenolic Hydroxy Groups

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