A Short and Efficient Synthesis of Mono-substituted 1,4,7-Triazacyclononanes

Abstract

A convenient synthesis of 1,4,7-Triazacyclononane (tacn) derivatives substituted with a single pendant donor group is described. Mono-substituted tacns with a hydroxylalkyl, an aminoalkyl, or a benzyl group are synthesized via efficient cyclization of inexpensive starting materials followed by detosylation.

Keywords:

• Triazacyclononane
• Pendant substituted macrocycle
• Mono-substituted tacn

Acknowledgment

We thank the structural Mass Spectra Group (Dr. L. Pannell, NIDDK, Bethesda, MD) for obtaining the mass spectra of compounds.