Synthesis of Some Pyridazine Glycosides

Abstract

Two N-glycosides 3 (A, C) of 6-(4-methoxyphenyl)-3(2H)-pyridazinone 2 and two O-glycosides 6 (A, B) of 6-(4-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone 5 were synthesized under phase transfer catalysis. Three O-glycosides 8 (A–C) of 2 were prepared by the Koenigs-Knoor reaction of 1 (A–C) with the silver salt 7 of 2. The compounds 3A, 8 (A–C) were treated by ammonia to obtain four new compounds 4A′, 9 (A′–C′). Their structures were confirmed by elemental analysis, IR, ¹H NMR.