Syntheses of 4-(3,5-Bisphenylmethylene-4-oxo-piperidin-1-yl)-4-oxo-but-2Z-enoic Acid Arylamides as Candidate Cytotoxic Agents

Abstract

The title compounds were designed and synthesized as candidate cytotoxic agents. They were synthesized by reacting 3,5-bisphenylmethylene-piperidin-4-one with the appropriate 3-arylcarbamoyl-acrylic acids. These reactions follow an unusual mechanism and deviate from the previously reported reactions on similar substrates.

Keywords:

• Arylmaleamic acids
• N-Acyl-3,5-bisphenylmethylene-4-piperidones
• Stereochemistry
• Molecular modeling

Acknowledgments

We thank Purdue Neuroscience Company, USA for financial support.