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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 7
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Original Articles

Syntheses of 4-(3,5-Bisphenylmethylene-4-oxo-piperidin-1-yl)-4-oxo-but-2Z-enoic Acid Arylamides as Candidate Cytotoxic Agents

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Pages 1211-1223 | Received 15 May 2002, Published online: 21 Aug 2006
 

Abstract

The title compounds were designed and synthesized as candidate cytotoxic agents. They were synthesized by reacting 3,5-bisphenylmethylene-piperidin-4-one with the appropriate 3-arylcarbamoyl-acrylic acids. These reactions follow an unusual mechanism and deviate from the previously reported reactions on similar substrates.

Acknowledgments

We thank Purdue Neuroscience Company, USA for financial support.

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