An Efficient Synthesis of 2-Alkylthio- 5-phenylmethylidene-4H-imidazolin-4-ones

Abstract

2-Alkylthio-5-phenylmethylidene-4H-imidazolin-4-ones 5 were synthesized by S-alkylation of thioimidazolinones 4, which were obtained via cyclization of carbodiimides 2 with Na₂S/HOAc. The direct reaction of carbodiimides 2 with butylthiol could not give 2-butylthio-4H-imidazolin-4-ones 3.

Keywords:

• 4H-Imidazolin-4-ones
• Aza-Wittig reaction
• Alkylation
• Synthesis

Acknowledgments

We gratefully acknowledge financial support of this work by the Natural Science Foundation of China (Project No. 20102001).