Catalytic Friedel–Crafts Acylation of Alkoxy Benzenes by Ferric Hydrogensulfate

Abstract

Friedel–Crafts acylation of alkoxy benzenes is achieved efficiently by reaction with aliphatic acid anhydrides in the presence of catalytic amounts of ferric hydrogensulfate, Fe(HSO₄)₃, in nitromethane. Alkyl benzenes and aryl halides, as well as aromatic anhydrides, remain intact under these conditions.

Keywords:

• Friedel-Crafts
• Acylation
• Ferric hydrogensulfate
• Catalysis
• Alkoxy benzenes

Acknowledgment

We are grateful to Razi University Research Council for financial support of this work.