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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 8
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Original Articles

A Synthesis of Racemic Thalidomide

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Pages 1375-1382 | Received 15 Jun 2002, Published online: 15 Aug 2006
 

Abstract

A synthesis of racemic thalidomide is described using formal [3+3] cycloaddition strategy as the key step. The total yield of thalidomide was 30% in three steps from ester 2.

Acknowledgment

The authors would like to thank the National Science Council of the Republic of China for financial support.

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