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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 9
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Original Articles

Synthesis and Characterization of 5-Substituted Novel Isoxazolidines Derived from 1,3-Dipolar Cycloaddition of Nitrones with Olefins: Studies of Antibacterial and Antifungal Activities

K. R. Ravi Kumar Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
,
H. Mallesha Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, India
&
K. S. Rangappa Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, IndiaCorrespondence[email protected]
Pages 1545-1555 | Received 17 Apr 2002, Published online: 16 Aug 2006
 
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Abstract

The synthesis, antibacterial and antifungal activities of a novel series of 5-substituted isoxazolidine derivatives [3a,b(i–viii)] were described. The synthesis of title compounds was achieved via a 1,3-dipolar cycloaddition of C-(4-biphenyl)-N-(4-methylphenyl)nitrone, C-(4-biphenyl)-N-(4-chlorophenyl) nitrone with monosubstituted alkenes.

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Related Research Data

Diastereoselective synthesis of atropisomeric pyrazolyl pyrrolo[3,4-d]isoxazolidines via pyrazolyl nitrone cycloaddition to facially divergent maleimides: intensive NMR and DFT studies
Source: Royal Society of Chemistry (RSC)
3-(6-Benz-yloxy-2,2-dimethyl-perhydro-furo[2,3-d][1,3]dioxol-5-yl)-5-(4-bromo-phen-yl)-2-phenyl-perhydro-pyrrolo[3,4-d]isoxazole-4,6-dione.
Source: (:unav)
Microwave‐Assisted Stereoselective 1,3‐Dipolar Cycloaddition of C,N‐Diarylnitrone (i.e., N‐(Arylmethylidene)benzenamine N‐Oxide) and Bis(arylmethylidene)acetone (=1,5‐Diarylpenta‐1,4‐dien‐3‐one): NMR and Crystal Analysis of Diastereoisomeric Bis(isoxazolidines)
Source: Wiley
3-(5-Substituted 2-Methoxyphenyl)-4-Nitro-2-Phenyl-5-Thiophene-2-yl-Isoxazolidines - Synthesis and Conformational Studies
Source: Informa UK Limited
(3R*,4R*,5S*)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R*)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.
Source: International Union of Crystallography
The crystal structures and Hirshfeld surface analysis of 6-(naphthalen-1-yl)-6a-nitro-6,6a,6b,7,9,11a-hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,11′-indeno[1,2-b]quinoxaline] and 6′-(naphthalen-1-yl)-6a′-nitro-6′,6a′,6b′,7′,8′,9′,10′,12a′-octahydro-2H-spiro[acenaphthylene-1,12′-chromeno[3,4-a]indolizin]-2-one
Source: International Union of Crystallography (IUCr)

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