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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 9
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Original Articles

A Straightforward Method for the Synthesis of Alkylidene and Arylidene Malonates Through Proline-Catalyzed Knoevenagel Condensation

Giuliana Cardillo Dipartimento di Chimica “G. Ciamician,”, Università di Bologna, Bologna, ItalyCorrespondence[email protected]
,
Serena Fabbroni Dipartimento di Chimica “G. Ciamician,”, Università di Bologna, Bologna, Italy
,
Luca Gentilucci Dipartimento di Chimica “G. Ciamician,”, Università di Bologna, Bologna, Italy
,
Massimo Gianotti Dipartimento di Chimica “G. Ciamician,”, Università di Bologna, Bologna, Italy
&
Alessandra Tolomelli Dipartimento di Chimica “G. Ciamician,”, Università di Bologna, Bologna, Italy
Pages 1587-1594 | Published online: 16 Aug 2006
 
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Abstract

A straightforward method for the synthesis of alkylidene/arylidene malonates and arylidene cyanoacetates, utilizing proline as an alternative to traditional catalysts is presented. A large number of unsaturated esters was obtained from the Knoevenagel reaction under very mild conditions and utilizing cheap reagents.

Acknowledgment

We thank MURST (Cofin 2000, FIRB project, and 60%) and the University of Bologna (funds for selected topics) for financial support.

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