Aqueous Trichloroacetic Acid: Another Useful Reagent for Highly Selective 5′-Desilylation of Multisilylated Nucleosides

Abstract

Highly selective 5′-desilylation of multisilylated nucleosides can be achieved in excellent yield by treatment with 4.2 M aqueous trichloroacetic acid:THF (1:4) at 0°C.

Keywords:

• Nucleoside
• Deprotection
• Selective desilylation

Acknowledgments

This work was supported by grants from the Texas Advanced Technology Research Program and the Robert A. Welch Foundation. X. F. Z. thanks members of the Scott group, especially Dr. Clotilde Pichon-Santander, for offering him invaluable help during his post-doctoral appointment at Texas A&M University.