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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 12
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Original Articles

A Novel Synthesis of N-Aryl-6-methylsulfanyl-4-pyrimidinones and Purine Analogues: The Reaction of Dimethyl N-Cyanodithioiminocarbonate with Cyanoacetanilides

Galal H. Elgemeie Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, EgyptCorrespondence[email protected]
,
Samia R. El-Ezbawy Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt
&
Soha A. Sood Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt
Pages 2095-2101 | Received 16 Sep 2002, Published online: 17 Aug 2006
 
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Abstract

A novel and efficient method for the synthesis of N-aryl-6-methylsulfanyl-4-oxopyrimidine-5-carbonitriles via the reaction of dimethyl N-cyanodithioiminocarbonate with substituted cyanoacetanilides has been investigated. (3)N-Aryl-2,5-diamino-7H-pyrazolo[3,4-d]-pyrimidin-4(3H)-one have also been prepared from the reaction of 6-sulfanylthio-N-aryl-4-pyrimidinones with hydrazines.

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