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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 13
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Original Articles

Microwave-Assisted Coupling of Carboxylic Acids to a Polymer Bound Hydrazine Linker

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Pages 2257-2262 | Received 09 Sep 2002, Published online: 17 Aug 2006
 

Abstract

A set of carboxylic acids, all being potential scaffolds for combinatorial chemistry or peptide synthesis, were coupled to a polymer bound aryl hydrazine linker using microwave irradiation in good yields. Improved yields and reduced reaction times were achieved by using microwave-assisted heating compared to conventional heating.

Acknowledgments

This work was financially supported by Amersham Biosciences and the Swedish Research Council.

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