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Abstract
Via Knoevenagel condensation of N-benzyl-4-piperidone with malononitrile some new 4-substituted N-benzyl-piperidines have been prepared. By means of these transformations an economic and large-scale synthesis of biologically important intermediate N-benzyl-piperidine-4-ethanol has been elaborated.
Acknowledgments
The authors wish to thank Márta Roczkov and Katalin Welker for technical assistance. Financial support of this research in the framework of 1/047 NKFP MediChem project is gratefully acknowledged.