Abstract
Controlled acetolysis of 1,2-O-isopropylideneglucofuranose derivative 1 in Ac2O:AcOH:H2SO4 at 0°C is reported to isolate 2-acetoxy dimethylmethylenoxy glucofuranose derivative 2 in quantitative yield. Utility of 2 for the synthesis of alpha linked nucleoside 5a is demonstrated.
Acknowledgment
PL thanks UGC-CSIR, New Delhi for financial support in the form of a Senior Research Fellowship.