Hypophosphorous Acid-Iodine: An Efficient and Mild Reagent for Cleavage of N–C Bond: Synthetic Communications: Vol 33, No 15

Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 33, 2003 - Issue 15

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Abstract

A mixture of hypophosphorous acid (H₃PO₂) and iodine in acetic acid can selectively cleave the N-alkyl bond in a variety of substituted heterocylic compounds in good to excellent yields without any damage to amide bond present in the substrates.

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Hypophosphorous Acid-Iodine: An Efficient and Mild Reagent for Cleavage of N–C Bond

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Hypophosphorous Acid-Iodine: An Efficient and Mild Reagent for Cleavage of N–C Bond

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