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Abstract
The one-step synthesis of ethyl 2-vinyloxazole-4-carboxylate is described. The reactivity of this synthetically useful oxazole fragment towards addition and Heck coupling was examined.
Acknowledgments
The financial support of the National Institutes of Health (GM-42641) is gratefully acknowledged. High resolution mass spectra were provided by the Washington University Mass Spectrometry Resource, an NIH Research Resource (Grant No. P41RR00954). F. A. is the recipient of a Richard W. Jobling Fellowship (2000–2001).