Arylation of Diethyl 2-Chloroazulene- 1,3-dicarboxylate with Grignard Reagent

Abstract

Reaction of diethyl 2-chloroazulene-1,3-dicarboxylate (2) with phenyl magnesium bromide, followed by oxidation with o-chloranil, gave diethyl 2-chloro-4-phenylazulene-1,3-dicarboxylate (3), diethyl 2-chloro-5-phenylazulene-1,3-dicarboxylate (4) and diethyl 6-phenylazulene-1,3-dicarboxylate (5).

Keywords:

• Azulenoids
• Arylation
• Nucleophilic substitution
• Oxidation

Acknowledgment

This study was financially supported by the National Science Council of the Republic of China (NSC89-2113-M-017-003).