Stereospecific Synthesis of trans-2,3-Diaryl Substituted 1-Aminocyclopropanecarboxylic Acid Derivatives

Guifa Su College of Chemistry and Chemical Engineering, Zhongshan University, Canton, P.R. China; Department of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, P.R. China; Department of Organic Chemistry, ICMA, University of Zaragoza-CSIC, Zaragoza, Spain; Department of Chemistry, 232 Choppin Hall, Louisiana State University, Baton Rouge, LA 70803, USA E-mail: [email protected]

Hongtao Mu Department of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, P.R. China

Danming Za Department of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, P.R. China

Longmei Zeng College of Chemistry and Chemical Engineering, Zhongshan University, Canton, P.R. China

Carlos Cativiela Department of Organic Chemistry, ICMA, University of Zaragoza-CSIC, Zaragoza, Spain

Robert P. Hammer Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA

Kaibei Yu Chengdu Analysis and Testing Center, Academia Sinica, Chengdu, P.R. China

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Abstract

The stereospecific syntheses of trans-2,3-diaryl-1-aminocyclopropanecarboxylic acid derivatives are reported. The key step is a 1,3-dipolar cycloaddition of phenyldiazomethane to (Z)-2-phenyl-4-arylidene-5(4H)-oxazolones, followed by the extrusion of nitrogen in situ.

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Acknowledgment

Financial support from the Foundation of Science and Technology Bureau of the Guangxi Zhuang Autonomous Region, People's Republic of China is gratefully acknowledged.

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Stereospecific Synthesis of trans-2,3-Diaryl Substituted 1-Aminocyclopropanecarboxylic Acid Derivatives

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Stereospecific Synthesis of trans-2,3-Diaryl Substituted 1-Aminocyclopropanecarboxylic Acid Derivatives

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