Trityl-Directed Regiospecific Synthesis of 2,3-Disubstituted Bioimidazoles

Abstract

We report an efficient trityl-directed regiospecific synthesis of 2,3-disubstituted-l-histdines and 2,3-disubstituted histamines starting from α-N-trifluoroacetyl-l-histidine methyl ester and α-N-trifluoroacetylhistamine respectively in five steps.

^# NIPER Communication no. 162.

Keywords:

• Bioimidazoles
• Homolytic free-radical reaction
• Trityl

Notes

^# NIPER Communication no. 162.