One Pot Synthesis of Aryldiazepinothiophenones

Abstract

Aryldiazepinothiophenones 2 were prepared from the reaction of o-phenylenediamines with acetone in the presence of 2-mercaptopropionic acid. Fused thiazolobenzodiazepines 3 along with fused thiazolobenzimidazoles 4 and 1,5-benzodiazepines 5 were obtained as by-products. The benzodiazepinothiophenone 2a and the benzodiazepine 5a were also isolated from the reaction of o-phenylenediamine with phorone.

Keywords:

• Aryldiazepinothiophenones
• Benzodiazepines
• o-Phenyl-enediamines
• 2-mercaptopropionic acid
• Thiophenones

Acknowledgment

We wish to thank the Hellenic General Secretariat of Research and Technology for Financial Support with ΠENEΔ 99, EΔ 427.