Abstract
Synth. Commun. 2003, 33, 3843
Unexpected ipso-Substitutions at the β-Carboline Nucleus
Oliver Kast and Franz Bracher*
Department Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität, Munich, Germany
Minisci-type radical carbamoylation of 1-bromo-β-carboline (1) gives the 3-substituted product in low yield, whereas 1-acetyl-β-carboline (3a) reacts under ipso-substitution of the acetyl group. Cyanations of the N-oxides of 1 and 3a occur under clean ipso-substitution of the groups in 1-position. 1-Methyl derivatives show no tendency to react under ipso-substitution.
Abstract
Synth. Commun. 2003, 33, 3851
Iodoform, a New Reagent in the Todd-Atherton Reaction
Grażyna Mielniczak and Andrzej Łopusiński*
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Łódź, Poland
An innovative and convenient application of the iodoform (1) as the reagent in the synthesis of phosphoramidates via Todd-Atherton reaction is described. The full stereoselectivity of this transformation using a 4-methyl-1,3,2-dioxaphosphinane model system was demonstrated.
Abstract
Synth. Commun. 2003, 33, 3861
Novel Method for the Synthesis of 1,2,4-Triazoles and 1,2,4-Triazol-3-ones
Hanen Chouaieb, Mongi Ben Mosbah, Mohamed Kossentini, and Mansour Salem*
Laboratoire de Chimie Appliquée : Hétérocycles, Corps Gras et Polymères Faculté des Sciences de Sfax, Sfax, Tunisia
Synthesis of tosylated 1,2,4-triazoles 2 and 1,2,4-triazol-3-ones 3 by condensation of N 1-tosylamidrazones 1 with acethychloride and ethyl chloroformate respectively.
Abstract
Synth. Commun. 2003, 33, 3869
A Simple and convenient multigram scale synthesis of hydroxyphenstatin: potential cancer cell growth inhibitor
Pedamallu Radha*
A. V. Rama Rao Research Foundation, Habshiguda, Hyderabad, India
The synthesis of Hydroxyphenstatin (2,3-dihydroxy-3′4′,5′4′-tetramethoxy-benzophenone) has been achieved by condensing 3,4,5-trimethoxybenzoic acid with pyrogallol and subsequent selective methylation.
Abstract
Synth. Commun. 2003, 33, 3875
Methyltrioxorhenium Catalyzed Oxidative Cleavage of α-Hydroxycarbonyl Compounds to Carboxylic Acids with Hydrogen Peroxide
Suman L. Jain, Vishal B. Sharma, and Bir Sain*
Chemical and Biosciences Division, Indian Institute of Petroleum, Dehradun, India
Methyltrioxorhenium catalyzed oxidative cleavage of a variety of α-hydroxycarbonyl compounds with hydrogen peroxide selectively yielded corresponding carboxylic acids in excellent yields.
Abstract
Synth. Commun. 2003, 33, 3879
Studies on Reactivity of BisolEfinic Diketo Sulfides/Sulfones. II
V. Padmavathi,* M. Rajagopala Sarma, T. V. Ramana Reddy, and D. Bhaskar Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Different novel bispyrazolines were prepared from bis(1-aryl-2-propen-1-one) sulfide/sulfone (1/2) with diazomethane and hydrazine hydrate.
Abstract
Synth. Commun. 2003, 33, 3891
TiCl4, Dioxane—A Facile and Efficient System for De- O -Benzylation, De- O -Allylation, and De- O -Xylylation of Phenolic Ethers
Perumal Rajakumar* and Venghatraghavan Murali
Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India
Abstract
Synth. Commun. 2003, 33, 3897
Selective and Practical Synthesis of Penciclovir
Tatsushi Toyokuni,* Joseph C. Walsh, Mohammad Namavari, Shirin S. Shinde, Jennifer R. Moore, Jorge R. Barrio, and Nagichettiar Satyamurthy
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Abstract
Synth. Commun. 2003, 33, 3907
Direct Conversion of Trimethylsilyl and Tetrahydropyranyl Ethers into Esters with Acid Chlorides in the Presence of Montmorillonite K-10
Barahman Movassagh* and Kobra Atrak
Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
A simple method is described for an efficient conversion of variety of trimethylsilyl and tetrahydropyranyl ethers into their corresponding esters with acid chlorides in the presence of montmorillonite K-10.
Abstract
Synth. Commun. 2003, 33, 3913
Synthesis and StrUcture Determinaiton of (2 S , 2′ S )-3-Phenyl-2-(pyrrolidin-2′-yl)propionic Acid
Jin Jing Yi, Ming Hua Zheng, and Guan Rong Tian*
Department of Chemistry, Yan Bian University, Yan Ji City, Ji Lin, China
Abstract
Synth. Commun. 2003, 33, 3919
Synthesis and Characterization of β-Diketonato Titanium Derivatives of Polyoxometalates
Jianghua He, Jianxin Li, Xiaohong Wang, and Jingfu Liu*
Department of Chemistry Northeast Normal University, Changchun, P.R. China
Novel β-diketonato titanium derivatives of mono-lacunary Keggin and Dawson type polyoxotungstates with heteroatom P have been prepared and characterized by elementary analysis, IR, 1H NMR and 183W NMR spectrometry. The results show that the complexes still retain the Keggin and Dawson structure, respectively.
Abstract
Synth. Commun. 2003, 33, 3929
Solvent-Free Tetrahydropyranylation of Alcohols with sulfamic Acid as Reusable Catalyst
Bo Wang, Li-Ming Yang,* and Ji-Shuan Suo
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China
Tetrahydropyranylation of various alcohols with 3,4-dihydro-2H-pyran have been investigated using H2NSO3H as a cost-effective catalyst under mild and solvent-free conditions.
Abstract
Synth. Commun. 2003, 33, 3935
Synthesis of Novel Chalcone Analogues of Ferrocene Biarenes
Qing-Bao Song,1,* Xiao-Nian Li,1 Tian-Hua Shen,1 Shang-Dong Yang,2 Gen-Rong Qiang,1 Xiao-Li Wu,2 and Yong-Xiang Ma2,*
1College of Chemical Engineering, Zhejiang Key Laboratory of Heterogeneous Catalysis, Zhejiang University of Technology, Hangzhou, P.R. China; 2National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China
The chalcones 5 and 9 were synthesized via Suzuki cross-coupling reaction of bromoarene with arylboronic acid.
Abstract
Synth. Commun. 2003, 33, 3943
A Novel Efficient Synthesis of α-Keto Triflates
Jong Chan Lee* and Yong Chan Lee
Department of Chemistry, Chung-Ang University, Seoul, Korea
A new efficient method for the conversion of ketones to α-keto triflates is described.
Abstract
Synth. Commun. 2003, 33, 3947
The Oxidation of 3-Aryl-1-Propenes by Oxidative System of RuCl3-NaIo4-Phase Transfer Catalyst
Yoshifumi Yuasa,1,* Shiroshi Shibuya,2 and Yoko Yuasa2
1Technical Engineering Department, Fine Chemical Division, Takasago International Corporation, Hiratsuka, Kanagawa, Japan; 2School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
Abstract
Synth. Commun. 2003, 33, 3953
Preparation of Resin-Bound Bismethylene Cyclic Malonic Acid Ester and Facile Solid-Phase Synthesis of 2-Alkylthio-4(1 H )-Quinolone and 2-Alkyl-4(1 H )-Quinolone
Jing Tang1 and Xian Huang1,2,*
1Department of Chemistry, Zhejiang University, Campus Xixi, Hangzhou, P.R. China; 2Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China
Abstract
Synth. Commun. 2003, 33, 3961
A Mild and Efficient Oxidation of Alcohols to Ketones with Iodosobenzene/(Salen) Manganese Complex
Sung Soo Kim* and Galina Borisova
Department of Chemistry and Center for Chemical Dynamics, Inha University, Incheon, South Korea
Abstract
Synth. Commun. 2003, 33, 3969
First Synthesis of Some New 1-Aryl-4-Ethoxycarbonyl-5-DimethylaminomethyleneamiNo-1,2,3-triazole Under Vilsmeier Conditions
Mindong Chen,1,* Youfei Zheng,1 Guizhi Gao,1 Shuxian Fan,1 and Shijie Lu2
1Department of Environmental Science, Nanjing Institute of Meteorology, Nanjing, P.R. China; 2State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
Abstract
Synth. Commun. 2003, 33, 3977
A Novel Catechol Compound, an Unusual Side Reaction Product of a β-Ketoester with Pyruvic Aldehyde and Its Inhibition by Sodium Dithionite
Takeaki Kato,2 Masao Mochizuki, Shigeru Okano,‡ and Noritada Matsuo1,*
1Agricultural Chemicals Research Laboratory, Sumitomo Chemical Co., Ltd., Takarazuka, Hyogo, Japan; 2Matsugaki Chemical Industries Co. Ltd., Kita-ku, Osaka, Japan
The structure of an usual catechol byproduct in the aldol condensation of the salt of 3-oxo-6-heptenoate and pyruvic aldehyde, and the discovery of an additive to inhibit its formation are described.
Abstract
Synth. Commun. 2003, 33, 3983
High-Throughput Synthesis of Alkylbenzophenones with Indium Triflate in the Absence of Solvents Using Microwave
Hideko Koshima* and Masashi Kubota
Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan
Solvent-free Friedel-Crafts acylation catalyzed with indium triflate by microwave heating is reported.
Abstract
Synth. Commun. 2003, 33, 3989
Synthesis of Polysubstituted Pyrimidines from Ketene Dithioacetals Using KF/Al2O3 Catalyst
Shen-Yi Yu* and Ya-Xian Cai
The Key Laboratory of Science and Technology of Controllable Chemical Reactions, Ministry of Education, Beijing University of Chemical Technology, Beijing, P.R.China
Abstract
Synth. Commun. 2003, 33, 3997
A Simple Preparation of DiArylmethanes by Oxidative Friedel-Crafts Reaction of Methyl-Substituted Benzenes with o -Chloranil
Tomoshige Kobayashi* and Sheikh Maksudur Rahman
Department of Chemistry, Faculty of Science, Shinshu University, Matsumoto, Japan
Oxidative Friedel-Crafts reaction of methyl-substituted benzenes with o-chloranil provided substituted diphenylmethanes.