An Efficient One-Pot Synthesis of N-Methoxy-N-methylamides from Carboxylic Acids

Abstract

Several N-methoxy-N-methylamides were prepared by the reaction of the corresponding carboxylic acids with N,O-dimethylhydroxylamine hydrochloride at room temperature using trichloromethyl chloroformate in the presence of triethylamine in excellent yields.

Keywords:

• Carboxylic acids
• N-Methoxy-N-methylamides
• Weinreb amides
• Trichloromethyl chloroformate
• N,O-Dimethyl-hydroxylamine hydrochloride

Acknowledgment

We thank Hankyong National University Analysis Center for using NMR and mass facilities.