A Convenient Route to Symmetric Phosphate, Phosphorothioate, and Phosphoroselenoate of AZT and D4T

Qiang Xiao The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, China

Yong Ju The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, ChinaCorrespondence[email protected]

Yufen Zhao The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing, ChinaCorrespondence[email protected]

Abstract

The symmetric phosphate, phosphonothioate, and phosphonoselenoate derivatives of AZT and D4T were synthesized in an expeditious way and high yields. The structures of these compounds were confirmed by the NMR and ESI-MS methods.

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Acknowledgment

We are grateful to the NSFC (No. 20132020, No. 20175026, and No. 20172033), the Ministry of Science and Technology, the Chinese Ministry of Education and Tsinghua University for financial support.

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A Convenient Route to Symmetric Phosphate, Phosphorothioate, and Phosphoroselenoate of AZT and D4T

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A Convenient Route to Symmetric Phosphate, Phosphorothioate, and Phosphoroselenoate of AZT and D4T

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