Ring‐Expanded C‐Nucleoside Analogues of Tiazofurin

Abstract

Novel 1,3‐dioxane C‐nucleoside analogues of tiazofurin 2‐[2‐(hydroxymethyl)‐1,3‐dioxan‐5‐methyl‐5‐yl] 1,3‐thiazole‐4‐carboxamide, 2‐[2‐(hydroxymethyl)‐1,3‐dioxan‐5‐ethyl‐5‐yl] 1,3‐thiazole‐4‐carboxamide and 2‐[5‐(hydroxymethyl)‐1,3‐dioxan‐5‐methyl‐2‐yl] furan, 2‐[5‐(hydroxymethyl)‐1,3‐dioxan‐5‐methyl‐2‐yl] thiophen have been synthesized from DMPA and DMBA. Their conformational characteristics have been investigated.

Keywords:

• Ring‐expanded
• Tiazofurin
• 2′,3′‐Dideoxynucleoside
• C‐Nucleosides
• Synthesis
• Conformation

Acknowledgment

We are grateful to the National Natural Science Foundation of China (project 20172049) for the financial support.