Synthesis and Characterization of Some α,β‐Didehydroamino Acid Derivatives

Abstract

A mild Horner–Wadsworth–Emmons reaction is described. Treatment 4‐substituted cyclohexanones with trimethyl 1‐(N‐benzyloxycarbonyl) phosphonoacetate afforded the corresponding α,β‐didehydroamino acid derivatives.

Keywords:

• HWE olefination
• Substituted cyclohexanones
• Trimethyl 1‐(N‐benzyloxycarbonyl)phosphonoacetate
• DBU
• α,β‐Didehydroamino acid

Acknowledgments

Financial support from the Foundation of Educational Bureau of the Guangxi Zhuang Autonomous Region, People's Republic of China and the International Cooperation Agency of Spain are gratefully acknowledged.