Abstract
Synthesis of 2‐alkylamino‐3‐fluoropyridines from 2‐chloro‐3‐fluoropyridine using palladium‐catalyzed coupling reaction under Buchwald conditions is described.
Acknowledgments
The authors wish to thank Ms. Jean Kaysen for assistance with manuscript preparation and Drs. Charles Ross and Harri Ramjit for mass spectrometric measurements.
Notes
aWagaw and Buchwald reported a 73% yield of cyclohexyl‐pyridin‐2‐yl‐amine after 22 hours at 70°C in toluene.