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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 9
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Original Articles

Improvements in Aldol Reactions with Diketopiperazines

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Pages 1589-1597 | Received 07 Oct 2003, Published online: 16 Aug 2006
 

Abstract

Precipitation of products by using dichloromethane as solvent permits an efficient aldol‐type reaction between 1,4‐diacetyl‐2,5‐piperazinedione and aromatic aldehydes catalyzed by K t BuO/ t BuOH independently of the electrophilic character of the aryl ring. A simple method to obtain 3‐methyl‐2,4,5‐trimethoxybenzaldehyde is also reported.

Acknowledgment

Financial support of this research from CICYT (SAF2000‐0130/99) and a FPI fellowsip (J. F. González) is gratefully acknowledged.

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