Abstract
An improved synthesis of [11C]raclopride is reported. The precursor desmethyl‐raclopride was synthesized from 3,5‐dichloro‐2,6‐dimethoxybenzoic acid and (S)‐(−)‐2‐aminoethyl‐1‐ethylpyrrolidine via a straightforward, four‐step synthetic approach with 29% overall chemical yield. [11C]Raclopride was prepared by O‐[11C]methylation of the precursor with [11C]methyl triflate and purification with a semi‐preparative HPLC method in 20–34% radiochemical yield, based on [11C]methyl bromide, decay corrected to end of bombardment (EOB).
Acknowledgments
This work was partially supported by the Indiana 21st Century Research and Technology Fund, and the Lilly Endowment Inc. to the Indiana Genomics Initiative (INGEN) of Indiana University.