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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 10
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Original Articles

One‐Pot Synthesis of Pyrazole‐5(3)‐carboxyamides

, , , , , , , , , & show all
Pages 1915-1923 | Received 03 Jan 2004, Published online: 20 Aug 2006
 

Abstract

A convenient one‐pot synthesis of eight pyrazole‐5(3)‐carboxyamides from the reaction of the 5(3)‐trichloromethylpyrazoles with amines, in good yield, is reported. These reactions show that the trichloromethyl group is a convenient precursor to carboxyamide groups.

Acknowledgments

The authors thank the Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq, Contracts No. 46.0804/00–6 and 480067/01–5), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) and CAPES for financial support and fellowships.

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