A Ring Expansion Strategy in Antiviral Synthesis: A Novel Approach to TAK‐779

Abstract

A synthesis of TAK‐779 that relies on construction of a key carboxylic acid intermediate by a ring expansion with TMSCHN₂ is described.

Keywords:

• Ring transformations
• Amines
• Suzuki reactions
• Coupling reaction

Acknowledgments

The author would like to thank Mr. Virgil L. Styles, Dr. Wieslaw Kazmierski, and Dr. Paul Feldman for informative discussions during the course of this work and for critical reading of this manuscript.