A Simple and Convenient Synthesis of HEPT Analogues via a One‐Pot Reduction–Sulfenylation Reaction

Guangfu Sun Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P.R. China

Yunyan Kuang Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P.R. China

Suxi Wang Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P.R. China

Fener Chen Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P.R. ChinaCorrespondence[email protected]

Abstract

The one‐pot reduction–sulfenylation of 5‐alkyl‐6‐chlorouracils (1) with diaryl disulfides (2) and sodium borohydride in methanol was carried out to afford 1‐[(2‐hydroxyethoxy)methyl]‐6‐(phenylthio)thymine HEPT analogues in good to excellent yields.

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A Simple and Convenient Synthesis of HEPT Analogues via a One‐Pot Reduction–Sulfenylation Reaction

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A Simple and Convenient Synthesis of HEPT Analogues via a One‐Pot Reduction–Sulfenylation Reaction

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