Synthesis of Chiral Nitrones from N‐Fmoc Amino Acids and N‐Fmoc Dipeptides

Abstract

In this work is presented a synthetic procedure for the preparation of chiral nitrones from N‐Fmoc protected amino acids and dipeptides. The nitrone functional group can replace the carboxyl unit of amino acid and peptide systems and can be inserted into the peptide chain. The introduction of the 1,3‐dipole in peptide segments can improve the solubility and the stability toward enzymatic degradation.

Keywords:

• Chiral nitrones
• Amino acids
• Peptides
• Fluorenylmethoxycarbonyl group

Acknowledgment

This work was supported by MIUR financial grants.