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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 18
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Original Articles

Microwave‐Assisted Efficient Synthesis of Dihydropyrimidines in Solvent‐Free Condition

Maryam Mirza‐Aghayan Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P.O. Box 14335‐186, Tehran, IranCorrespondence[email protected]
,
Mohammad Bolourtchian Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P.O. Box 14335‐186, Tehran, Iran
&
Maryam Hosseini Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P.O. Box 14335‐186, Tehran, Iran
Pages 3335-3341 | Received 19 Jan 2004, Published online: 10 Jan 2011
 
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Abstract

An efficient synthesis of 3,4‐dihydropyrimidinones from an aldehyde, a ketoester, and a urea or thiourea using a catalytic amount of ferric chloride hexahydrate is described. Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds under solvent‐free conditions and in a short reaction time and with good yield.

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