Regioselectivity of Reactions of Nitrogen and Carbon Nucleophiles with Coumarin Derivatives

Abstract

Reaction of various 3‐substituted coumarins with nitrogen and carbon nucleophiles appears to involve, in all cases examined, exclusive, direct substitution at the exocyclic C‐1′ electrophilic center.

Keywords:

• Coumarins
• Regioselectivity
• Nucleophilic substitution

Acknowledgments

The authors thank the National Research Foundation (NRF) and Rhodes University for generous financial support.