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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 19
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Original Articles

Conversion of α‐Amino Acids into Nitriles by Oxidative Decarboxylation with Trichloroisocyanuric Acid

Gene A. Hiegel Department of Chemistry and Biochemistry, California State University, Fullerton, California, 92834, USACorrespondence[email protected]
,
Justin C. Lewis Department of Chemistry and Biochemistry, California State University, Fullerton, California, 92834, USA
&
Jason W. Bae Department of Chemistry and Biochemistry, California State University, Fullerton, California, 92834, USA
Pages 3449-3453 | Received 27 May 2004, Published online: 10 Jan 2011
 
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Abstract

Trichloroisocyanuric acid oxidation of α‐amino acids in water or methanol in the presence of pyridine produces nitriles with one less carbon in good yields and of high purity.

Acknowledgment

This research was supported in part by a grant from the CSU Special Fund for Research, Scholarship, and Creative Activity to G. A. H. and funds from the Southern California Academy of Sciences Research Training Program to J. W. B.

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Related Research Data

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