Improved Yields in the Synthesis of Spin‐Labeled Fatty Acids

Abstract

Paramagnetic amide side products (6a–g) have been isolated from the reaction mixture in the synthesis of spin‐labeled fatty acids of the doxyl type. After their hydrolysis to the corresponding acid, 7, the overall yield of spin‐labeled fatty acids is significantly increased compared with published procedures.

Keywords:

• Amide hydrolysis
• Fatty acid spin probe

Acknowledgments

This research work was financially supported by the Ministry of Education, Science and Sports of the Republic of Slovenia. The authors thank the EPR Centre, Jožef Stefan Institute, for EPR spectra; the MS Centre, Jožef Stefan Institute, for mass spectra; and Prof. Roger Pain for his critical reading of the manuscript.