The Facile Route to Stereodefined Alkenyl‐Substituted Pyrimidines

Abstract

The Suzuki–Miyaura type cross‐coupling reactions of various chloropyrimidines with stereodefined alkenylboronic acids giving the corresponding alkenyl‐substituted pyrimidines were studied. The experiments discovered that the reaction is stereospecific and highly regioselective. In the coupling of 2,4‐dichloropyrimidine and 2,4,6‐trichloropyrimidine, the reaction occured at 4‐position prior to 2‐position.

Keywords:

• Chloropyrimidines
• Organoboronic acid
• Suzuki–Miyaura cross‐coupling reaction

Acknowledgments

We thank the NNSF of China for financial support (NO.20272073).