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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 20
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Original Articles

Organic Reactions in Ionic Liquids: Gewald Synthesis of 2‐Aminothiophenes Catalyzed by Ethylenediammonium Diacetate

Yi Hu Ningbo Institute of Technology, Zhejiang University, Ningbo, 315104, P.R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P.R. China
,
Zhen‐Chu Chen Ningbo Institute of Technology, Zhejiang University, Ningbo, 315104, P.R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P.R. ChinaCorrespondence[email protected]
,
Zhang‐Gao Le Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P.R. China
&
Qin‐Guo Zheng Pharmaceutical Science Research Institute, Aston University, Aston Triangle, Birmingham, B4 7ET, UK
Pages 3801-3806 | Received 10 May 2004, Published online: 19 Apr 2010
 
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Abstract

Ionic liquids based on 1‐butyl‐3‐methylimidazolium tetrafluoroborate (BmimBF4) and 1‐butyl‐3‐methylimidazolium hexafluorophosphate (BmimPF6) were used as reusable alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Gewald synthesis of 2‐aminothiophenes. Significant rate enhancement and improvement of the yield were observed. The ionic liquids containing catalyst EDDA were recycled several times with no decreases in yields and reaction rates.

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