Mild Microwave‐Assisted Hydrolysis of Acetals Under Solvent‐Free Conditions

Yanhong He Department of Organic and Bioorganic Chemistry, Lund University, P.O. Box 124, Lund, 22100, Sweden

Martin Johansson Department of Organic and Bioorganic Chemistry, Lund University, P.O. Box 124, Lund, 22100, Sweden

Olov Sterner Department of Organic and Bioorganic Chemistry, Lund University, P.O. Box 124, Lund, 22100, SwedenCorrespondence[email protected]

Abstract

Acetals are efficiently hydrolyzed with silica gel‐supported pyridinium tosylate moistened with water in solvent‐free conditions under microwave irradiation. The method is efficient and mild, with acid‐sensitive 3‐hydroxyacetals and 3‐methoxyacetals being hydrolyzed in minutes in good yields.

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Acknowledgments

Financial support from the Swedish Research Council is gratefully acknowledged. The authors thank Dr. Ulf Ellervik and Dr. Andréas Meijer for the generous gift of protected sugars.

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Mild Microwave‐Assisted Hydrolysis of Acetals Under Solvent‐Free Conditions

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Mild Microwave‐Assisted Hydrolysis of Acetals Under Solvent‐Free Conditions

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