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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 23
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Original Articles

An Efficient Procedure for the Synthesis of Benzimidazole Derivatives Using Yb(OTf)3 as Catalyst Under Solvent‐Free Conditions

Limin Wang Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Lu, Shanghai, 200237, P. R. ChinaCorrespondence[email protected] [email protected]
,
Jia Sheng Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Lu, Shanghai, 200237, P. R. China
,
He Tian Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Lu, Shanghai, 200237, P. R. China
&
Changtao Qian Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China
Pages 4265-4272 | Received 31 Mar 2004, Published online: 10 Jan 2011
 
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Abstract

o‐Diaminobenzene derivatives react smoothly with ortho‐esters in the presence of 0.5 mol% of Yb(OTf)3 under solvent‐free conditions to afford the corresponding benzimidazole derivatives in good to excellent yields. In addition, Yb(OTf)3 can be easily recovered almost quantitatively from the aqueous layer after the reaction was completed, and it could be reused with no loss of activity.

Acknowledgment

We thank the National Nature Science Foundation of China and the Science Foundation of East China University of Science and Technology for their financial support.

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