Direct Formation of 2,3,5‐Trichloropyridine and its Nucleophilic Displacement Reactions in Ionic Liquid

Abstract

Reaction of trichloroacetaldehyde and acrylonitrile in the presence of a catalytic amount of copper (I) chloride in ionic liquid afforded 2,3,5‐trichloropyridine, fluorination of which with KF and CsF in ionic liquid afforded 3,5‐dichloro‐2‐fluoropyridine and 5‐chloro‐2,3‐dichloropyridine. Reaction of 2,3,5‐trichloropyridine, 3,5‐dichloro‐2‐fluoropyridine, or 5‐chloro‐2,3‐dichloropyride with 2‐(4‐hydroxyphenoxy)propionates in ionic liquid afforded the corresponding 2‐aryloxylpropionates in good yields.

Keywords:

• Trichloroacetaldehyde
• Acrylonitrile
• 2,3,5‐Trichloropyridine
• Ionic liquid
• Nucleophilic displacement reactions

Acknowledgment

Project 20272043 was supported by The National Nature Science Foundation of China. This work was also supported by The National Nature Science Foundation of Zhejiang Province (M203001).