KF‐Alumina Catalyzed One‐Pot Synthesis of Pyrido[2,3‐d]Pyrimidine Derivatives

Abstract

A series of pyrido[2,3‐d]pyrimidine derivatives was synthesized by the reaction of arylaldehyde, malononitrile, and 4‐amino‐2,6‐dihydroxylpyrimidine in ethyl alcohol at 80°C catalyzed by KF‐Al₂O₃. Compared with other synthetic methods, this new method has the advantage of easier workup, milder reaction conditions, and good yields.

Keywords:

• Pyrido[2,3‐d]pyrimidine
• Aromatization
• KF‐Al₂O₃ synthesis

Acknowledgment

We are grateful to the Foundation of the “Surpassing Project” of Jiangsu Province and Natural Science Foundation of the Education Committee of Jiangsu Province for financial support.