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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 23
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Original Articles

Synthesis of Substituted 1,4‐Dihydropyridines in Water Using Phase‐Transfer Catalyst Under Microwave Irradiation

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Pages 4349-4357 | Received 16 Jun 2004, Published online: 10 Jan 2011
 

Abstract

The synthesis of various substituted 1,4‐dihydropyridines has been achieved by the reaction of aldehydes, ethyl/methyl acetoacetates, and ammonium acetate in water using phase‐transfer catalyst under microwave irradiation. Compared to the classical Hantzsch's reaction conditions, this new method consistently has the advantage of good yields and short reaction times. Bifunctional compounds containing two units have been synthesized using dialdehyde as precursor in good yields.

Acknowledgment

This work was supported by the CAS, MOST, NSFC, and the University of Science and Technology of China.

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