Enantioselective Aldol‐Type Reaction Using Diketene

Abstract

An aldol‐type reaction catalyzed by a Ti‐(S)‐BINOL complex using with a diketene as substrate is described herein. The complex derived from 1.0 molar equivalent of Ti(O‐i‐Pr)₄ and 2.0 molar equivalents of (S)‐BINOL gave (S)‐isopropyl 5‐hydroxy‐7‐phenyl‐3‐oxo‐6‐heptenoate with high enantioselectivity.

Keywords:

• Aldol‐type reaction
• Diketene
• Enantioselective
• Titanium‐BINOL complexes

Acknowledgments

We thank the technical staff at the Materials Analysis Center of our institute.