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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 24
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Original Articles

Organic Reactions in Ionic Liquids: Ionic Liquid Promoted Knoevenagel Condensation of Aromatic Aldehydes with (2‐Thio)Barbituric Acid

Yi Hu Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P. R. China
,
Zhen‐Chu Chen Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P. R. ChinaCorrespondence[email protected]
,
Zhang‐Gao Le Ningbo Institute of Technology, Zhejiang University, Ningbo, P. R. China; Department of Chemistry, Zhejiang University (Xi Xi Campus), Hangzhou, 310028, P. R. China; Department of Applied Chemistry, East China Institute of Technology, Fuzhou, P. R. China
&
Qin‐Guo Zheng Pharmaceutical Science Research Institute, Aston University, Aston Triangle, Birmingham, United Kingdom
Pages 4521-4529 | Received 01 Jul 2004, Published online: 10 Jan 2011
 
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Abstract

The Knoevenagel condensation of aromatic aldehydes with (2‐thio)barbituric acid proceeded efficiently in reusable ionic liquids, EAN, BmimBF4, and BmimPF6 at room temperature in the absence of any catalyst with high yields.

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