Efficient Synthesis of Biologically Interesting Dehydro‐α‐Lapachone and α‐Lapachone

Abstract

An efficient synthesis of biologically active dehydro‐α‐lapachone and α‐lapachone has been carried out starting from 2‐hydroxy‐1,4‐naphthoquinone by a tandem Knoevenagel‐electrocyclic reaction.

Keywords:

• Dehydro‐α‐lapachone
• α‐Lapachone
• 2‐Hydroxy‐1,4‐naphthoquinone
• Knoevenagel‐electrocyclic reaction

Acknowledgment

This work was supported by the Korea Research Foundation Grant (KRF‐2003‐041‐C00183). Dr. Ronald Tepper in discussion of this work is greatly appreciated.