Titanium Tetraisopropoxide Catalyzed Synthesis of Base‐Sensitive Cyanoguanidine Analogs

John K. Lynch Neurological and Urological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USACorrespondence[email protected]

Peggy Huang Neurological and Urological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA

Hao Bai Neurological and Urological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA

Abstract

The synthesis of base‐sensitive cyanoguanidine analogs of potent potassium channel openers was accomplished in two steps by converting the thiourea to a carbodiimide followed by Ti(OiPr)₄ catalyzed addition of cyanamide in dichloromethane.

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Titanium Tetraisopropoxide Catalyzed Synthesis of Base‐Sensitive Cyanoguanidine Analogs

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Titanium Tetraisopropoxide Catalyzed Synthesis of Base‐Sensitive Cyanoguanidine Analogs

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