An Efficient Synthesis of Double 2‐Alkylthio‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones

Abstract

Double 2‐alkylthio‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones 6 were synthesized by S‐alkylation of double 2‐thioxo‐5‐phenylmethylidene‐4‐imidazolidinone 5, which was obtained via cyclization of vinyl isothiocyanate 4 with ethylenediamine.

Keywords:

• 4H‐Imidazol‐4‐ones
• aza‐Wittig reaction
• alkylation
• synthesis

Acknowledgments

We gratefully acknowledge financial support of this work by the Natural Science Foundation of China (Project No. 20102001) and the Natural Science Foundation of Hubei Education Commission of China (Project No. 2003A002).