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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 1
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Original Articles

Solvent‐Free Microwave Michael Addition Between EMME and Various Nucleophiles

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Pages 79-87 | Received 18 Aug 2004, Published online: 05 Aug 2006
 

Abstract

Michael addition reaction between EMME and various O, S, N nucleophiles were investigated in the presence of catalysts such as KF, KOH, or K(OCCH3)3 under solvent‐free conditions either neat or on alumina as solid support. Compared to low reactivity of alcohols (40 to 80% yields according to aliphatic chain), aniline or thiophenol gave good to excellent yields (90–99%).

Acknowledgments

This work was supported by grant from the Kyungsung University research foundation (2003) and Basic Research Program of the Korea Science & Engineering Foundation (KOSEF R05‐2003‐000‐11732‐0).

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